M.Wt: 435.08

Formula: C24H23FN4O3

Solubility: Soluble in DMSO, weakly in EtOH

Purity: 99%

Storage: -20C 2 years

AZD2281(olaparib) is a highly potent and selective phtalazinone-type PARP-inhibitor with IC 50 of 5nM (PARP-1) and 1 nM (PARP-2). AZD2281(olaparib)shows activity in BRCA-1 deficient breast cancer cells. Cell-kill in the presence of the alkylator methylmethansulfonate is potentiated by a factor of 25

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